Human Opiorphin, a natural antinociceptive modulator of opioid-dependent pathways
A Wisner, E Dufour, M Messaoudi… - Proceedings of the …, 2006 - National Acad Sciences
Mammalian zinc ectopeptidases play important roles in turning off neural and hormonal
peptide signals at the cell surface, notably those processing sensory information. We report
here the discovery of a previously uncharacterized physiological inhibitor of enkephalin-
inactivating zinc ectopeptidases in humans, which we have named Opiorphin. It is a QRFSR
peptide that inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-
endopeptidase, hNEP (EC 3.4. 24.11), and human ecto-aminopeptidase, hAP-N (EC 3.4 …
peptide signals at the cell surface, notably those processing sensory information. We report
here the discovery of a previously uncharacterized physiological inhibitor of enkephalin-
inactivating zinc ectopeptidases in humans, which we have named Opiorphin. It is a QRFSR
peptide that inhibits two enkephalin-catabolizing ectoenzymes, human neutral ecto-
endopeptidase, hNEP (EC 3.4. 24.11), and human ecto-aminopeptidase, hAP-N (EC 3.4 …
